Lab makes 3-D enzyme mimicking architectures using full pallet of synthetic chemistry
The Martell group’s research focuses on making artificial enzymes and artificial receptors by combining biomolecules with synthetic molecules. “We synthetically modify individual DNA arms by using functional groups that are not found in naturally occur- ring amino acids and cofactors, therefore broadening the scope of our reactivity,” said Prof. Jeffrey Martell. “We then rely on complementary base-pairing for the arms to self-assemble into a 3-D cage, such that the attached functional groups are displayed into a central cavity.”